3-(Trifluoromethyl)benzaldehyde → 2-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

HRID 2056395노트

반응식

HRID 2056395 반응식
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[F:28][C:29]([F:39])([F:38])C1C=C(C=CC=1)C=O>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]([C:29]([F:39])([F:38])[F:28])[CH:19]=2)[O:6][C:7]=1[CH3:8]

참가 물질

4

반응물 3

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

생성물 1

HCID 224936812-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

실험 절차

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyl-oxazole, diacetylmonoxime and 3-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(3-trifluoromethylphenyl)oxazole.

출처 및 근거

ORD 기록
ord-3021904d0aca4836bbc9dcd79ec30134
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335671B2

반응 노트

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