Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl piperazine-1-carboxylate → 4-[6-(2-CYCLOPROPYLETHYLCARBAMOYL)PYRIDAZIN-3-YL]PIPERAZINE-1-CARBOXYLIC Acid T-Butyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 반응물 | 6-Chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamide | HCID 65561565 | — |
| 생성물 | 4-[6-(2-CYCLOPROPYLETHYLCARBAMOYL)PYRIDAZIN-3-YL]PIPERAZINE-1-CARBOXYLIC Acid T-Butyl Ester | HCID 11624983 | — |
반응 단계
Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazine-1-carboxylic acid t-butyl ester, the title compound was obtained as a white solid (47% yield). 1H NMR (400 MHz, CDCl3) δ 8.04-7.95, 6.97, 3.62-3.54, 1.59-1.44, 1.34-1.23, 0.72-0.62, 0.45-0.36, 0.06-0.04. MS (ES+) m/z 376.3 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335658B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-82a1851f6bbe4914bb375116c7e6ad29 |
| 출처 메모 | uspto-grants-2008_02 |