Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[2-(Trifluoromethyl)benzoyl]piperazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid [2-(2-FLUOROPHENYL)ETHYL]AMIDE
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[2-(Trifluoromethyl)benzoyl]piperazine | HCID 16733784 | — |
| 반응물 | 6-Chloropyridazine-3-carboxylic acid [2-(2-fluorophenyl)ethyl]amide | HCID 60860171 | — |
| 생성물 | 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid [2-(2-FLUOROPHENYL)ETHYL]AMIDE | HCID 66849618 | — |
반응 단계
Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid [2-(2-fluorophenyl)ethyl]amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white powder (70.7% yield). 1H NMR (400 MHz, CDCl3) δ 8.04, 7.95, 7.75-7.72, 7.63, 7.55, 7.36, 7.22-7.15, 7.05-6.97, 4.07-4.02, 3.89-3.83, 3.79-3.67, 3.35-3.32, 2.96.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335658B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-381dfe04632b4770aaa3dad7e6a1768f |
| 출처 메모 | uspto-grants-2008_02 |