Methanesulfonyl chloride → 2-((1S)-6-Bromo-3,4-dihydro-1H-2-benzopyran-1-yl)ethyl methanesulfonate

반응식

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C@H:10]([CH2:11][CH2:12][OH:13])[O:9][CH2:8][CH2:7][C:6]=2[CH:14]=1.[CH3:15][S:16](Cl)(=[O:18])=[O:17].CS(OCC[C@H]1C2C=CC(C(N)=O)=CC=2CCO1)(=O)=O>>[CH3:15][S:16]([O:13][CH2:12][CH2:11][C@H:10]1[C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:14][C:6]=2[CH2:7][CH2:8][O:9]1)(=[O:18])=[O:17]

참가 물질

반응물 3

HCID 31297Methanesulfonyl chloride

HCID 536878432-((1S)-6-Bromo-3,4-dihydro-1H-2-benzopyran-1-yl)ethanol

HCID 865960122-[(1S)-6-(aminocarbonyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate

생성물 1

HCID 865960212-((1S)-6-Bromo-3,4-dihydro-1H-2-benzopyran-1-yl)ethyl methanesulfonate

실험 절차

The title compound was prepared from 2-((1S)-6-bromo-3,4-dihydro-1H-2-benzopyran-1-yl)ethanol and methanesulfonyl chloride, as described for the preparation of 2-[(1S)-6-(aminocarbonyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate.

출처 및 근거

ORD 기록: ord-7f2ac4380e0b411da8f77048e34ab004
출처 데이터셋: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07335660B2

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