Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → L-Tryptophan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Decane, 1-isothiocyanato- | HCID 90535 | — |
| 생성물 | L-Tryptophan | HCID 6305 | — |
반응 단계
To a suspension of compound AA (9.1 g) in dry N,N′-dimethylformamide (15 ml) was added n-decylisothiocyanate (1.2 ml). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was poured on to Bondesil 40 μM C8 resin (400 g) that had been prewashed with methanol (1 L) and water (1 L). The product was eluted with methanol (800 ml) after being first washed with water (800 ml) followed by 20% acetonitrile in water (800 ml). Evaporation of the methanol gave compound BB as a yellow solid (7.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335726B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-efc564ca20644543b396101ebb2cd497 |
| 출처 메모 | uspto-grants-2008_02 |