Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenemethanamine, 2,5-dichloro- → N-(2,5-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenemethanamine, 2,5-dichloro- | HCID 457600 | — |
| 반응물 | 2-(Isoquinolin-5-YL)acetic acid | HCID 12018708 | — |
| 반응물 | 2-(Isoquinolin-5-yl)propanoic acid | HCID 22337638 | — |
| 생성물 | N-(2,5-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide | HCID 10043982 | — |
반응 단계
The title compound was prepared using the procedure described in Example 222B using 2,5-dichlorobenzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 359 (M+H)+; MS (ESI−) m/z 357 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.54 (d, J 7.1, 3H), 4.20 (m, 2H), 4.53 (q, J 7.1, 1H), 7.06 (s, 1H), 7.32 (d, J 8.4, 1H), 7.44 (d, J 8.4, 1H), 7.51 (s, 1H), 7.78 (t, J 7.8, 1H), 7.90 (d, J 6.5, 1H), 8.16 (d, J 8.1, 1H), 8.26 (d, J 6.4, 1H), 8.60 (d, J 6.2, 1H), 8.65 (t, J 5.8, 1H), 9.49 (s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335678B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-905ac60bda5447a1a84258d0a3dfebb7 |
| 출처 메모 | uspto-grants-2008_02 |