3,4-Difluorobenzene-1-sulfonyl chloride → HCID 178484850, 화합물

HRID 2057231

반응식

HRID 2057231 반응식
Cl.[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH:14][CH3:15])[CH2:10][CH2:9]1.[F:16][C:17]1[CH:18]=[C:19]([S:24](Cl)(=[O:26])=[O:25])[CH:20]=[CH:21][C:22]=1[F:23]>>[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C@H:8]1[CH2:9][CH2:10][C@H:11]([N:14]([CH3:15])[S:24]([C:19]2[CH:20]=[CH:21][C:22]([F:23])=[C:17]([F:16])[CH:18]=2)(=[O:26])=[O:25])[CH2:12][CH2:13]1

참가 물질

3

반응물 2

HCID 27369133,4-Difluorobenzene-1-sulfonyl chlorideHCID 178484847HCID 178484847, 화합물

생성물 1

HCID 178484850HCID 178484850, 화합물

실험 절차

In analogy to example 11.9, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and 3,4-difluoro-benzenesulfonyl chloride (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-3,4-difluoro-N-methyl-benzenesulfonamide which was used directly in the next steps see Example 12.55-12.56 and 12.65 and 12.66.

출처 및 근거

ORD 기록
ord-e7446ac5ab7e4661803c7d83010c3849
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335687B2

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