Trifluoroacetic acid → HCID 178484796, 화합물

HRID 2057271노트

반응식

HRID 2057271 반응식
C(O[C:6]([N:8](C)[C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH2:11][CH2:10]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:6][NH:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH2:13][CH2:14]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178486032HCID 178486032, 화합물

생성물 1

HCID 178484796HCID 178484796, 화합물수율 166.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

200 mg (0.53 mmol) of trans-Methansulfonic acid 5[-4-(tert-butoxy carbonyl-methyl-amino)-cyclohexyl)-pentyl ester, dissolved in 2 ml of CH2Cl2, was treated with 2 ml of TFA. After stirring for 20 min at RT, the solution was concentrated in vacuo to yield 245 mg of pure trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentylester.trifluoroacetic acid salt, MS: 278 (MH+).

후처리

  1. concentrationthe solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-56d1b190e44e451795026f9058cab3f7
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335687B2

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