Trifluoroacetic acid → 1H,2H,3H,4H,5H,11H,11aH-[1,4]diazepino[1,2-a]indole

HRID 2057360노트

반응식

HRID 2057360 반응식
[CH2:1]1[C:7]2=[CH:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:6]2[CH2:5][CH2:4][CH2:3][NH:2]1.B.C1COCC1.FC(F)(F)C(O)=O>O1CCCC1>[CH2:1]1[CH:7]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:6]2[CH2:5][CH2:4][CH2:3][NH:2]1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 33471AzepindoleHCID 2723981Borane;tetrahydrofuran

생성물 1

HCID 124246601H,2H,3H,4H,5H,11H,11aH-[1,4]diazepino[1,2-a]indole수율 75%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In an operation carried out in a manner similar to that described in Example I but employing 22 grams of 2,3,4,5-tetrahydro-1H-[1,4]-diazepino[1,2-a]indole, milliliters of 1 M BH3.THF in tetrahydrofuran and milliliters of trifluoroacetic acid, a 75 percent yield of 2,3,4,5,11,11a-hexahydro-1H-[1,4]-diazepino[1,2-a]indole was obtained as determined by GLC on the isolated product.

출처 및 근거

ORD 기록
ord-c7147503121f4138945336cc6beb9ab5
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04210590

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