Morpholine → Moclobemide

HRID 2057461

반응식

HRID 2057461 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]2[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:10][CH2:9][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[O:7])=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 2450271-(4-Chlorobenzoyl)aziridine

생성물 1

HCID 4235Moclobemide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

55.4 G. of p-chlorobenzoylaziridine and 26.5 g. of morpholine are boiled in 250 ml. of toluene for 2 hours under reflux. The solution is then cooled to room temperature, whereupon crystals separate out. The solution which crystallizes is allowed to stand overnight in a refrigerator. Thereafter, the product is removed by filtration, washed with toluene and recrystallized from isopropanol, and 75.9 g. of p-chloro-N-(2-morpholinoethyl)-benzamide are obtained, which is identical to the product obtained in Example 1.

후처리

  1. customseparate out
  2. customThe solution which crystallizes
  3. customThereafter, the product is removed by filtration
  4. washwashed with toluene
  5. customrecrystallized from isopropanol, and 75.9 g

출처 및 근거

ORD 기록
ord-6a997b4ee6b14561a49738f88756156d
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04210754

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