Acetone → HCID 178461615, 화합물

HRID 2057567

반응식

HRID 2057567 반응식
[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][CH2:9][C@H:10]2[O:15][C@@H:14]([O:16][C:17]3[C:26](=[O:27])[C:25]4[C:24]([OH:28])=[CH:23][C:22]([OH:29])=[CH:21][C:20]=4[O:19][C:18]=3[C:30]3[CH:31]=[CH:32][C:33]([OH:37])=[C:34]([OH:36])[CH:35]=3)[C@H:13]([OH:38])[C@@H:12]([OH:39])[C@@H:11]2[OH:40])[C@H:5]([OH:41])[C@H:4]([OH:42])[C@H:3]1[OH:43].[CH3:44][C:45]([CH3:47])=[O:46].ClC(OC)=O>CN(C)C=O>[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][CH2:9][C@H:10]2[O:15][C@@H:14]([O:16][C:17]3[C:26](=[O:27])[C:25]4[C:24]([OH:28])=[CH:23][C:22]([OH:29])=[CH:21][C:20]=4[O:19][C:18]=3[C:30]3[CH:31]=[CH:32][C:33]([OH:37])=[C:34]([OH:36])[CH:35]=3)[C@H:13]([OH:38])[C@@H:12]([OH:39])[C@@H:11]2[OH:40])[C@H:5]([OH:41])[C@H:4]([OH:42])[C@H:3]1[OH:43].[CH2-:44][C:45]([CH3:47])=[O:46]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 6586Methyl chloroformateHCID 5280805Rutin

생성물 1

HCID 178461615HCID 178461615, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

15 grams of rutin are dissolved in 60 cc of dimethylformamide. After addition of 100 cc of acetone, 15 cc of methyl chloroformate are added dropwise while agitating the mixture. Since the reaction is exothermic, the mixture is maintained at ambient temperature with cooling. At the end of 6 hours, the mixture is evaporated under vacuum. The residue is taken up in 500 cc of water. The solution is extracted with ether. The residual aqueous phase is extracted with ethyl acetate. After evaporation of the organic phase, about 10 grams of rutin acetonide is obtained, which can then be recrystallized.

후처리

  1. additionare added dropwise
  2. temperaturewith cooling
  3. customAt the end of 6 hours, the mixture is evaporated under vacuum
  4. extractionThe solution is extracted with ether
  5. extractionThe residual aqueous phase is extracted with ethyl acetate
  6. customAfter evaporation of the organic phase

출처 및 근거

ORD 기록
ord-12f4f7814d3b45ec9f93baa466eef585
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04211772

연결된 노트

불러오는 중…