HCID 54119678, 화합물 → 2'-Fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine

HRID 2057582노트

반응식

HRID 2057582 반응식
C([O:4][C@@H:5]1[C@@H:9]([CH2:10][O:11]C(=O)C2C=CC=CC=2)[O:8][C@@H:7]([N:20]2[CH:27]=[C:26]([Br:28])[C:24]([NH2:25])=[N:23][C:21]2=[O:22])[C@H:6]1[F:29])(=O)C>N>[F:29][C@H:6]1[C@H:5]([OH:4])[C@@H:9]([CH2:10][OH:11])[O:8][C@H:7]1[N:20]1[CH:27]=[C:26]([Br:28])[C:24]([NH2:25])=[N:23][C:21]1=[O:22]

참가 물질

3

반응물 1

HCID 54119678HCID 54119678, 화합물

생성물 1

HCID 1723922'-Fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine수율 81.3%

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-bromocytosine (1.0 g) is dissolved in saturated methanolic ammonia (100 ml) and the solution is left standing for 24 hours at room temperature. The solvent is removed in vacuo and the residue was crystallized from ethanol to give 560 mg of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-bromocytosine, m.p. 201°-202°.

후처리

  1. waitthe solution is left
  2. customThe solvent is removed in vacuo
  3. customthe residue was crystallized from ethanol

출처 및 근거

ORD 기록
ord-bab5abc43c2c408b95c115f7ddb52da4
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04211773

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