Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → HCID 178426523, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | p-Tolylthiourea | HCID 722833 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | HCID 178426523 | HCID 178426523 | — |
반응 단계
4-Tolylthiourea (33.2 g., 0.2 mole) in 200 ml. acetone is heated under reflux for 3 hrs. with methyliodide (31.4 g., 0.221 mole). Solvent is removed in vacuo and the resulting 2-methyl-1-(4-tolyl)-2-thiopseudourea hydroiodide dissolved in 200 ml. tert-butanol. Pyrrolidine (28.4 g., 0.4 mole) is added and the mixture heated at reflux for 18 hrs. The reaction mixture is cooled, diluted with ether and the resulting solid separated. Recrystallization from acetone-ether affords N-(4-tolyl)-1-pyrrolidinecarboximidamide hydroiodide, m.p. 166°-168° C. Conventional treatment of the salt in CH2Cl2 with aqueous (10-20%) NaOH affords the corresponding free base.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04211867 |
| 출처 데이터셋 | uspto-grants-1980_07 |
| ORD ID | ord-994d0c81d6cc48d5a2230df986a0a5a2 |
| 출처 메모 | uspto-grants-1980_07 |