Ethanol → 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol

HRID 2057679

반응식

HRID 2057679 반응식
[F:1][C:2]([F:12])([F:11])[C:3](=O)[CH2:4][C:5]([O:7]CC)=O.[C:13]1([NH:19][NH2:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(O)C>O>[C:13]1([N:19]2[C:5](=[O:7])[CH:4]=[C:3]([C:2]([F:1])([F:11])[F:12])[NH:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 7516PhenylhydrazineHCID 67793Ethyl 4,4,4-trifluoroacetoacetate

생성물 1

HCID 8927172-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 184 parts of ethyl trifluoroacetoacetate, 120 parts of phenylhydrazine, 200 parts by volume of ethanol and 20 parts by volume of 22° Be hydrochloric acid was heated under reflux, with stirring, for one hour, then 500 parts of water were added and the product was cooled in ice. The yellow precipitate obtained was filtered off, drained, washed, with a small portion of chilled toluene until decoloration took place. Thereafter it was dried in an oven (50° C.). 215 parts of 1-phenyl-3-trifluoromethyl-5-pyrazolone was obtained of which the melting point was 193° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperaturethe product was cooled in ice
  4. customThe yellow precipitate obtained
  5. filtrationwas filtered off
  6. washwashed, with a small portion of chilled toluene until decoloration
  7. customThereafter it was dried in an oven (50° C.)

출처 및 근거

ORD 기록
ord-762834c77d5a461aae4e75d7897052eb
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04212647

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