Potassium Carbonate → Ethyl 5-phenylbenzofuran-2-carboxylate

HRID 2057967

반응식

HRID 2057967 반응식
[C:1]1([C:7]2[CH:14]=[C:11]([CH:12]=O)[C:10]([OH:15])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:17](C(OCC)=O)[C:18]([O:20][CH2:21][CH3:22])=[O:19].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:15][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:12][C:11]=3[CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 69637Diethyl bromomalonateHCID 122646584-Hydroxy-(1,1'-biphenyl)-3-carbaldehyde

생성물 1

HCID 20329644Ethyl 5-phenylbenzofuran-2-carboxylate

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 0.99 g of 1A, 0.96 g of diethyl bromomalonate and 1.25 g of anhydrous potassium carbonate in 20 ml of 2-butanone was refluxed for 10 hours. The solvent was evaporated under reduced pressure. The residue was cooled, poured into 100 ml of water and extracted with ether. The extract was washed with cold 5% sodium hydroxide solution and water and then concentrated under reduced pressure. The residue was recrystallized from ethanol to give ethyl 5-phenylbenzofuran-2-carboxylate (1B), as white crystals, mp: 109°-110° C.

후처리

  1. temperaturewas refluxed for 10 hours
  2. customThe solvent was evaporated under reduced pressure
  3. temperatureThe residue was cooled
  4. additionpoured into 100 ml of water
  5. extractionextracted with ether
  6. washThe extract was washed with cold 5% sodium hydroxide solution and water
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-198325f99e0341759bfdc909f8e0367d
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04213998

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