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Tetrahydrofuran → N-[N-[4-(2,2,2,-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-chloro-N-methylbenzenesulfonamide

HRID 2058110
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HRID 2058110 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]([CH3:15])[C:12](Cl)=[O:13])(=[O:10])=[O:9].O1CCCC1.[CH3:21][NH:22][C:23]1[N:28]=[C:27]([O:29][CH2:30][C:31]([F:34])([F:33])[F:32])[CH:26]=[C:25]([CH3:35])[N:24]=1>C(N(CC)CC)C>[F:34][C:31]([F:32])([F:33])[CH2:30][O:29][C:27]1[CH:26]=[C:25]([CH3:35])[N:24]=[C:23]([N:22]([CH3:21])[C:12]([N:11]([CH3:15])[S:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])(=[O:10])=[O:9])=[O:13])[N:28]=1
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참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 201898672-Methylamino-4-(2,2,2-trifluorethoxy)-6-methylpyrimidineHCID 20189879N-[(2-chlorophenyl)sulfonyl]-N-methylcarbamyl chloride

생성물 1

HCID 20189885N-[N-[4-(2,2,2,-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-chloro-N-methylbenzenesulfonamide

시약·촉매·용매 1

HCID 8471Triethylamine
용매

실험 절차

To 18 parts of N-[(2-chlorophenyl)sulfonyl]-N-methylcarbamyl chloride in 300 parts of tetrahydrofuran containing 10 parts of triethylamine is added 22 parts of 2-methylamino-4-(2,2,2-trifluoroethoxy)-6-methylpyrimidine. After stirring at reflux for 10 hours, the precipitated salts are filtered off and the filtrate is concentrated to yield N-[N-[4-(2,2,2,-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-chloro-N-methylbenzenesulfonamide.

후처리

  1. temperatureat reflux for 10 hours
  2. filtrationthe precipitated salts are filtered off
  3. concentrationthe filtrate is concentrated

출처 및 근거

ORD 기록
ord-dcb08d40f0b5451f8f53caebe82162cd
출처 데이터셋
uspto-grants-1980_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04214890

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