2,4-Dichlorophenol → HCID 23349979, 화합물

HRID 2058195노트

반응식

HRID 2058195 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].Br[CH2:11][C:12](=[O:18])[C:13]([O:16][CH3:17])([CH3:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:11][C:12](=[O:18])[C:13]([O:16][CH3:17])([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 84492,4-DichlorophenolHCID 11430Potassium CarbonateHCID 1278370276336-55-5

생성물 1

HCID 23349979HCID 23349979, 화합물수율 85.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
-20 °C

실험 절차

A stirred mixture of 13.04 g (0.08 mole) of 2,4-dichlorophenol, 15.61 g (0.08 mole) 1-bromo-3-methoxy-3-methyl-2-butanone, and 11.1 g (0.08 mole) powdered potassium carbonate in 300 ml acetonitrile was heated at reflux temperature for 30 minutes. The reaction mixture was cooled, filtered, and the solvent evaporated from the filtrate. The residual oil was taken up in hexane and cooled to -20° C., whereupon the product separated as a white crystalline solid. There was thus obtained 19 g (85.7% yield) of 1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone, m.p. 45.5°-47.5° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature for 30 minutes
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered
  5. customthe solvent evaporated from the filtrate
  6. customseparated as a white crystalline solid

출처 및 근거

ORD 기록
ord-94e719e0b8644da6af17b1cdb3e70968
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04215127

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