Bromine → HCID 23349975, 화합물

HRID 2058196노트

반응식

HRID 2058196 반응식
[Br:1]Br.[Cl:3][C:4]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:5]=1[O:6][CH2:7][C:8](=[O:14])[C:9]([O:12][CH3:13])([CH3:11])[CH3:10].S(=O)(O)[O-].[Na+]>C(OCC)C>[Br:1][CH:7]([O:6][C:5]1[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:4]=1[Cl:3])[C:8](=[O:14])[C:9]([O:12][CH3:13])([CH3:11])[CH3:10]

참가 물질

5

반응물 3

HCID 24408BromineHCID 23349979HCID 23349979, 화합물HCID 23665763Sodium Bisulfite

생성물 1

HCID 23349975HCID 23349975, 화합물수율 99%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Bromine (10.73 g, 0.067 mole) was slowly added to a stirred solution of 18.6 g (0.067 mole) of 1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone in 350 ml diethyl ether containing 0.2 g aluminum chloride at about 3° C. After the addition, the mixture was stirred an additional 30 minutes, then poured into aqueous sodium bisulfite. The organic layer was separated, extracted with sodium bicarbonate solution, dried using MgSO4, and the solvent evaporated. There was thus obtained 23.6 g (99% yield) of 1-bromo-1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone.

후처리

  1. additionAfter the addition
  2. customThe organic layer was separated
  3. extractionextracted with sodium bicarbonate solution
  4. customdried
  5. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-86c30effc1cd423487761862734802a7
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04215127

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