Methanol → 2-(4-Tolyl)propanoic acid

HRID 2058547

반응식

HRID 2058547 반응식
CS(O[C:6]1[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:7]=1[CH:8]([CH3:12])[C:9]([OH:11])=[O:10])(=O)=O.CO.[H][H]>[Pd].C(N(CC)CC)C>[CH3:17][C:15]1[CH:14]=[CH:13][C:7]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:6][CH:16]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 204498532-Methane-sulphonyloxy-4-methyl-hydratropic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1508662-(4-Tolyl)propanoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8471Triethylamine용매

실험 절차

To a solution of 77.5 g. of 2-methane-sulphonyloxy-4-methyl-hydratropic acid in 600 ml. of methanol 84 ml. of triethyl amine and 6 g. of a 5% palladium on charcoal catalyst are obtained, and the mixture is hydrogenated at 25° C. until a calculated amount of hydrogen is used up. Catalyst is filtered off and the filtrate is evaporated. The residue is taken up in water and the solution is acidified with a 20% aqueous hydrochloric acid solution. The separated 4-methyl-hydratropic acid is extracted with chloroform and the chloroform extract is dried over sodium sulphate. Evaporation of the solution affords 4-methyl-hydratropic acid.

후처리

  1. filtrationCatalyst is filtered off
  2. customthe filtrate is evaporated
  3. extractionThe separated 4-methyl-hydratropic acid is extracted with chloroform
  4. extractionthe chloroform extract
  5. dry with materialis dried over sodium sulphate
  6. customEvaporation of the solution

출처 및 근거

ORD 기록
ord-caf604b794494a1dbde6433d385b6d9a
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04317920

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