Benzylaniline → 1-ethyl-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide

반응식

[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([P:17](Cl)(Cl)=[O:18])[CH3:16]>>[CH2:15]([P:17]1(=[O:18])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH2:1][N:8]1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:16]

참가 물질

반응물 2

HCID 66028Benzylaniline

HCID 70596Phosphonic dichloride, ethyl-2회

생성물 1

HCID 130374881-ethyl-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide수율 6%

실험 절차

The procedure of Example 1 was employed utilizing N-benzylaniline and ethyl phosphonic dichloride. The reaction of the dilithio compound and the ethyl phosphonic dichloride was conducted at -76° C. to yield 1-ethyl-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (0.45 g, 6% yield) as a pale yellow solid having a melting point of 116°-120° C. and the following analysis:

후처리

customwas conducted at -76° C.

출처 및 근거

ORD 기록: ord-cfd1e921fb744e2fbf2daf51fbc52236
출처 데이터셋: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04319913

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