Dimethylamine → N,N-Dimethyl-N'-phenyl-benzamidine

HRID 2059004

반응식

HRID 2059004 반응식
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)(Cl)=O.[CH3:20][NH:21][CH3:22]>C(Cl)Cl>[CH3:20][N:21]([CH3:22])[C:1](=[N:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 7168BenzanilideHCID 24386Thionyl Chloride

생성물 1

HCID 351862N,N-Dimethyl-N'-phenyl-benzamidine수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Into a slurry of 19.7 g of benzanilide (m.p. 162°-164° C.) in 200 ml of methylene chloride was added a solution of 12.0 g of thionylchloride in 50 ml of methylene chloride. After the addition was completed and the reaction mixture was stirred for one hour at room temperature, gaseous dimethylamine was introduced until the solution became saturated. Workup by filtration, waterwash, removal of the solvent and distillation afforded N,N-dimethyl-N'-phenylbenzamidine in 18.6 g or 83% yield.

후처리

  1. additionAfter the addition
  2. filtrationWorkup by filtration, waterwash, removal of the solvent and distillation

출처 및 근거

ORD 기록
ord-10df2198bc5e4c8187b258816a5af1ba
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04321202

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