Ethyl dichlorophosphate → 17-(Acetyloxy)-6-methylenepregn-4-ene-3,20-dione

HRID 2059168노트

반응식

[C:1]([O:4][C@:5]1([C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][CH2:24]2)[C@:20]2([CH3:21])[C:15](=[CH:16][C:17](=[O:27])[CH2:18][CH2:19]2)[CH2:14][CH2:13]3)[CH2:10][CH2:9]1)[C:6](=[O:8])[CH3:7])(=[O:3])[CH3:2].[CH2:28](OP(Cl)(Cl)=O)C>>[C:1]([O:4][C@:5]1([C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][CH2:24]2)[C@:20]2([CH3:21])[C:15](=[CH:16][C:17](=[O:27])[CH2:18][CH2:19]2)[C:14](=[CH2:28])[CH2:13]3)[CH2:10][CH2:9]1)[C:6](=[O:8])[CH3:7])(=[O:3])[CH3:2]

참가 물질

반응물 2

HCID 15158Ethyl dichlorophosphate

HCID 10156152Hydroxyprogesterone acetate

생성물 1

HCID 9443617-(Acetyloxy)-6-methylenepregn-4-ene-3,20-dione

실험 절차

Analogously to Example 42, 1.0 g of 17α-acetoxy-4-pregnene-3,20-dione is reacted with 3.8 ml of ethyldichlorophosphate and worked up, thus obtaining 510 mg of 17α-acetoxy-6-methylene-4-pregnene-3,20-dione, mp 231°-233° C.

출처 및 근거

ORD 기록: ord-c8a6ba6b83f74c4eac49cc539efe833a
출처 데이터셋: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04322349

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