Plomestane → HCID 86738325, 화합물

HRID 2059304노트

반응식

HRID 2059304 반응식
[CH2:1]([C@@:4]12[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16](=[O:22])[CH2:15][CH2:14]4)[CH2:11][CH2:10][C:9]1=[CH:8][C:7](=[O:23])[CH2:6][CH2:5]2)[C:2]#[CH:3]>O1CCOCC1.CCOCC>[CH2:1]([C@@:4]12[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16](=[O:22])[CH2:15][CH2:14]4)[CH2:11][CH2:10][C:9]1=[CH:8][C:7](=[O:23])[CH:6]=[CH:5]2)[C:2]#[CH:3]

참가 물질

4

반응물 1

HCID 9904788Plomestane

생성물 1

HCID 86738325HCID 86738325, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of 150 mg of 10-(2-propynyl)-estr-4-ene-3,17-dione, and 300 mg of dichlorodicyanoquinone in 10 ml of dioxane is refluxed for 20 hours. The mixture is cooled and diluted with ether and then washed with aqueous sodium carbonate and dried. The solvent is evaporated and the residue is chromatographed on silica gel in ethyl acetate/hexane to give 10-(2-propynyl)-estra-1,4-diene-3,17-dione melting at about 200°-201° C. This compound has the following structural formula ##STR11##

후처리

  1. temperatureis refluxed for 20 hours
  2. temperatureThe mixture is cooled
  3. washwashed with aqueous sodium carbonate
  4. customdried
  5. customThe solvent is evaporated
  6. customthe residue is chromatographed on silica gel in ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-4826164723a24b618e15a576aa0fbd0e
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04322416

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