홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → [2-(1-Benzyl-1H-pyrazol-4-yl)-6-methoxy-benzofuran-3-yl]-(3,4,5-trimethoxyphenyl)-methanone

HRID 2059600
노트
인쇄 미리보기

반응식

HRID 2059600 반응식
I[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[OH:10].[CH2:11]([N:18]1[CH:22]=[C:21]([C:23]#[CH:24])[CH:20]=[N:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH3:25][O:26][C:27]1[CH:28]=[C:29](I)[CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34].[C:38](=O)([O-])[O-:39].[K+].[K+]>CO.C(OCC)(=O)C>[CH2:11]([N:18]1[CH:22]=[C:21]([C:23]2[O:10][C:3]3[CH:4]=[C:5]([O:8][CH3:9])[CH:6]=[CH:7][C:2]=3[C:24]=2[C:38]([C:29]2[CH:28]=[C:27]([O:26][CH3:25])[C:32]([O:33][CH3:34])=[C:31]([O:35][CH3:36])[CH:30]=2)=[O:39])[CH:20]=[N:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 2981335-Iodo-1,2,3-trimethoxybenzeneHCID 114140152-Iodo-5-methoxyphenolHCID 574219391-benzyl-4-ethynyl-1H-pyrazole

생성물 1

HCID 11641809[2-(1-Benzyl-1H-pyrazol-4-yl)-6-methoxy-benzofuran-3-yl]-(3,4,5-trimethoxyphenyl)-methanone

시약·촉매·용매 2

HCID 887
Methanol
용매
HCID 8857Ethyl Acetate용매

실험 절차

This compound was prepared by application of the general procedure to 2-iodo-5-methoxy-phenol, 1-benzyl-4-ethynyl-1H-pyrazole and 3,4,5-trimethoxy-iodo-benzene. The crude product was stirred with potassium carbonate (excess) in methanol to hydrolyse ester by-products and submitted to silica-gel flash chromatography (eluent=2:1 hexanes:ethyl acetate) to afford the title compound as a yellow resin that crystallised after trituration in diethyl ether (31% yield). An analytical sample was obtained by preparative thin layer chromatography (eluent=2:1 hexane: ethyl acetate). 1H-NMR (CDCl3) δ 8.10 (s, 1H), 8.03 (s, 1H), 7.36-7.21 (m, 5H), 7.13 (d, J=8.7 Hz, 1H), 7.11 (s, 2H), 7.03 (d, J=2.0 Hz, 1H), 6.79 (dd, J 8.7, 2.0 Hz, 1H), 5.29 (s, 2H), 3.92 (s, 3H), 3.85 (s, 3H), 3.75 (s, 6H). 13C—NMR (CDCl3) δ 190.3, 158.2, 154.3, 153.3, 153.0, 142.4, 139.3, 135.7, 133.7, 130.3, 128.9, 128.3, 127.8, 121.8, 120.9, 114.0, 113.1, 112.3, 107.1, 95.6, 61.1, 56.4, 56.3, 55.8.

출처 및 근거

ORD 기록
ord-40903400bd634a5ba5286043893e6122
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08278290B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트