4-Aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride → (4-Aminooxan-4-yl)methanol

HRID 2059775

반응식

HRID 2059775 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].Cl.[NH2:8][C:9]1([C:15](O)=[O:16])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>C1COCC1>[NH2:8][C:9]1([CH2:15][OH:16])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 27344004-Aminotetrahydro-2H-pyran-4-carboxylic acid hydrochlorideHCID 21226445Aluminium lithium hydride

생성물 1

HCID 18316484(4-Aminooxan-4-yl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(4-Amino-tetrahydropyran-4-yl)-methanol is prepared by adding LAH (99%, 1.2 g), portionwise, to a stirred mixture of 4-aminotetrahydropyran-4-carboxylic acid hydrochloride (2.0 g, 11.0 mmol) in THF (30 mL) at 0° C. Upon completion of addition, the reaction mixture is warmed to room temperature and stirred for 1 hour. The reaction mixture is cooled to 0° C. and cautiously quenched by the portionwise addition of Na2SO4.10H2O (4 g). The reaction mixture is diluted with ethyl acetate, warmed to room temperature, and filtered through Celite to give the desired product.

후처리

  1. custom(4-Amino-tetrahydropyran-4-yl)-methanol is prepared
  2. additionUpon completion of addition
  3. temperatureThe reaction mixture is cooled to 0° C.
  4. customcautiously quenched by the portionwise addition of Na2SO4.10H2O (4 g)
  5. additionThe reaction mixture is diluted with ethyl acetate
  6. temperaturewarmed to room temperature
  7. filtrationfiltered through Celite

출처 및 근거

ORD 기록
ord-81dc67934e4448a5b7b563d5fa75a2b6
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278314B2

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