Triethylamine → N-Cyclopropyl-N-(2-hydroxyethyl)-4-methoxy-2,6-dimethylphenylsulfonamide

HRID 2059884노트

반응식

HRID 2059884 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10](Cl)(=[O:12])=[O:11])=[C:5]([CH3:14])[CH:4]=1.[CH:15]1([NH:18][CH2:19][CH2:20][OH:21])[CH2:17][CH2:16]1.C(N(CC)CC)C>ClCCl>[CH:15]1([N:18]([CH2:19][CH2:20][OH:21])[S:10]([C:6]2[C:7]([CH3:9])=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[CH3:14])(=[O:12])=[O:11])[CH2:17][CH2:16]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 159174964-Methoxy-2,6-dimethylbenzene-1-sulfonyl chlorideHCID 191005662-(Cyclopropylamino)ethan-1-ol

생성물 1

HCID 43577600N-Cyclopropyl-N-(2-hydroxyethyl)-4-methoxy-2,6-dimethylphenylsulfonamide수율 20%

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

반응 조건

온도
0 °C

실험 절차

A solution of 4-methoxy-2,6-dimethylbenzenesulfonyl chloride (7 mmol) in dichloromethane (12 ml) was slowly added dropwise to a solution of 2-(cyclopropylamino)ethanol (8 mmol) in dichloromethane (24 ml) and triethylamine (2.5 eq), cooled to 0° C. On completion of the addition the mixture was stirred for 90 min at 25° C. until the reaction was complete. The mixture was diluted with dichloromethane (200 ml) and washed with water and saturated NaCl solution. The organic phase was dried over MgSO4, filtered and concentrated completely to obtain the desired product. Yield: 20%

후처리

  1. additionOn completion of the addition the mixture
  2. washwashed with water and saturated NaCl solution
  3. dry with materialThe organic phase was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated completely

출처 및 근거

ORD 기록
ord-34cbee4094bb4a429442359c9aacafc7
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278319B2

반응 노트

불러오는 중…