Methanol → Methyl 2-(piperidin-2-yl)acetate hydrochloride

HRID 2059895노트

반응식

HRID 2059895 반응식
S(Cl)([Cl:3])=O.C(OC([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]1[CH2:18][C:19]([OH:21])=[O:20])=O)(C)(C)C.[CH3:22]O>>[ClH:3].[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]1[CH2:18][C:19]([O:21][CH3:22])=[O:20]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 50585361-Boc-2-Piperidineacetic Acid

생성물 1

HCID 13778732Methyl 2-(piperidin-2-yl)acetate hydrochloride수율 90%

실험 절차

Thionyl chloride (5.5 ml, 75 mmol) was added to a solution of 2-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester (6 g, 25 mmol) in methanol (60 ml) while stirring and the mixture was then refluxed for 16 h. The solvent was removed under vacuum and the crude product used in the next stage without purification. Yield: 90%

후처리

  1. temperaturethe mixture was then refluxed for 16 h
  2. customThe solvent was removed under vacuum
  3. customthe crude product used in the next stage without purification

출처 및 근거

ORD 기록
ord-86ecdd5a9d034b609630e1d9a6c6bff5
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278319B2

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