Hydrate;hydrochloride → 3-Aza-spiro[5.5]undecan-9-one hydrochloride

HRID 2059920노트

반응식

HRID 2059920 반응식
[O:1]=[C:2]1[CH2:19][CH2:18][C:5]2([CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:4][CH:3]1C(OC)=O.[ClH:24].O>>[ClH:24].[CH2:10]1[C:5]2([CH2:18][CH2:19][C:2](=[O:1])[CH2:3][CH2:4]2)[CH2:6][CH2:7][NH:8][CH2:9]1

참가 물질

3

반응물 2

HCID 21885828Hydrate;hydrochlorideHCID 67315804HCID 67315804, 화합물

생성물 1

HCID 673158423-Aza-spiro[5.5]undecan-9-one hydrochloride

실험 절차

To 3-tert-butyl 8-methyl 9-oxo-3-azaspiro[5.5]undecane-3,8-dicarboxylate (450 mg, 1.38 mmol) was added HCl—H2O (5 ml, 1:1) at 0° C. and the mixture was refluxed overnight. LCMS revealed complete consumption of the starting material and the mixture was concentrated to dryness. The crude product thus obtained was used directly in next step.

후처리

  1. temperaturethe mixture was refluxed overnight
  2. customconsumption of the starting material
  3. concentrationthe mixture was concentrated to dryness

출처 및 근거

ORD 기록
ord-67fe3e5ed43e4967bd792dcb48cac8bd
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278319B2

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