Ethyl bromoacetate → ethyl[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]acetate

반응식

FC(F)(F)C(O)=O.[CH3:8][CH:9]([O:11][C:12]1[CH:19]=[CH:18][C:17]([C:20]2[O:24][N:23]=[C:22]([C:25]3[C:26]([CH3:35])=[C:27]4[C:32](=[CH:33][CH:34]=3)[CH2:31][NH:30][CH2:29][CH2:28]4)[N:21]=2)=[CH:16][C:13]=1[C:14]#[N:15])[CH3:10].Br[CH2:37][C:38]([O:40][CH2:41][CH3:42])=[O:39].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.O>[CH2:41]([O:40][C:38](=[O:39])[CH2:37][N:30]1[CH2:29][CH2:28][C:27]2[C:32](=[CH:33][CH:34]=[C:25]([C:22]3[N:21]=[C:20]([C:17]4[CH:18]=[CH:19][C:12]([O:11][CH:9]([CH3:8])[CH3:10])=[C:13]([C:14]#[N:15])[CH:16]=4)[O:24][N:23]=3)[C:26]=2[CH3:35])[CH2:31]1)[CH3:42]