Nitric Acid → 2-Fluoro-4-methyl-6-nitrophenol

HRID 2060000노트

반응식

HRID 2060000 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11]>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[OH:9]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 27784852-Fluoro-4-methylphenol

생성물 1

HCID 227538152-Fluoro-4-methyl-6-nitrophenol수율 59%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 2-fluoro-4-methylphenol (500 mg, 3.96 mmol) in dichloromethane (5 mL) at room temperature was added dropwise nitric acid 70% (0.4 mL, 4.44 mmol) [exotherm observed]. After 15 min more washed with water, dried, evaporated to give 2-fluoro-4-methyl-6-nitrophenol (400 mg, 2.337 mmol, 59.0% yield) as a yellow solid.

후처리

  1. washAfter 15 min more washed with water
  2. customdried
  3. customevaporated

출처 및 근거

ORD 기록
ord-3411b2b478e94e3c8d81018a7364b2cb
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278328B2

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