참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tetramethoxypropane | HCID 66019 | — |
| 반응물 | 4-(Methylsulphonyl)phenylhydrazine | HCID 70142 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(4-methanesulfonyl-phenyl)-1H-pyrazole | HCID 21478015 | 79% |
반응 단계
To a solution of 4-(methylsulfonyl)phenylhydrazine (5.0 g, 26.8 mmol, 1.00 equiv) and 1,1,3,3-tetramethoxypropane (4.4 mL, 26.8, 1.0 equiv) in ethanol (37 mL) at rt was added concentrated HCl (2.8 mL). The resulting solution was heated at reflux for 1 hr, cooled to 0° C. and filtered to give 1-(4-methanesulfonyl-phenyl)-1H-pyrazole as a yellow solid (4.73 g, 79%). LCMS: (MH)+=223.1 (1.19 min).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08278337B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
|---|
| ORD ID | ord-cf5f16db644e423890a415b90ce6cc83 |
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| 출처 메모 | uspto-grants-2012_10 |
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