4-Chlorobenzoyl chloride → 1-(4-Chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

HRID 2060233노트

반응식

HRID 2060233 반응식
[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:2].[Cl:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][N:8]([C:16](=[O:17])[C:15]2[CH:19]=[CH:20][C:12]([Cl:11])=[CH:13][CH:14]=2)[CH2:7]1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 85014-Chlorobenzoyl chlorideHCID 12896002Ethyl pyrrolidine-3-carboxylate

생성물 1

HCID 593221851-(4-Chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester수율 79%

실험 절차

The title compound was prepared according to the method described for Preparation 2 using pyrrolidine-3-carboxylic acid ethyl ester (see Preparation 1) and 4-chloro-benzoyl chloride to afford the title compound as a pale yellow oil (3.02 g, 79%).

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-e9c2fa95e4284a39a76711f80f3879b5
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278343B2

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