4-Methylbenzaldehyde → 3-Hydroxy-1-(3-imidazol-1-yl-propyl)-4-phenyl-5-p-tolyl-1,5-dihydro-pyrrol-2-one

HRID 2060301노트

반응식

HRID 2060301 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[CH3:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1.C([O:21][C:22](=O)[C:23](=[O:31])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)C>C(O)C>[OH:31][C:23]1[C:22](=[O:21])[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:15]([C:14]2[CH:17]=[CH:18][C:11]([CH3:10])=[CH:12][CH:13]=2)[C:24]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

5

반응물 3

HCID 77254-MethylbenzaldehydeHCID 787361H-Imidazole-1-propanamineHCID 12292599Ethyl 2-oxo-3-phenylpropanoate

생성물 1

HCID 250994463-Hydroxy-1-(3-imidazol-1-yl-propyl)-4-phenyl-5-p-tolyl-1,5-dihydro-pyrrol-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

3-Imidazol-1-yl-propylamine (1 mmol) and 4-Methyl-benzaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-3-phenyl-propionic acid ethylester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

후처리

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

출처 및 근거

ORD 기록
ord-475a63bf865e41c189346b7a276f3402
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278345B2

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