Furfural → 5-Furan-2-yl-3-hydroxy-1-(3-imidazol-1-yl-propyl)-4-pentyl-1,5-dihydro-pyrrol-2-one

HRID 2060320노트

반응식

HRID 2060320 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH:15]=O.C([O:19][C:20](=O)[C:21](=[O:28])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])C>C(O)C>[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH:15]1[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:20](=[O:19])[C:21]([OH:28])=[C:22]1[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

참가 물질

5

반응물 3

HCID 7362FurfuralHCID 787361H-Imidazole-1-propanamineHCID 10888659Ethyl 2-oxooctanoate

생성물 1

HCID 579240955-Furan-2-yl-3-hydroxy-1-(3-imidazol-1-yl-propyl)-4-pentyl-1,5-dihydro-pyrrol-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

3-Imidazol-1-yl-propylamine (1 mmol) and Furan-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-octanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

후처리

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

출처 및 근거

ORD 기록
ord-1744b439609d4f2e86b9c88172d0c475
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278345B2

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