2-[4-(Hydroxymethyl)phenyl]propan-2-ol → 4-(2-Hydroxypropan-2-yl)benzaldehyde
반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1>C(OCC)(=O)C.ClCCl.O=[Mn]=O>[OH:12][C:9]([C:6]1[CH:7]=[CH:8][C:3]([CH:2]=[O:1])=[CH:4][CH:5]=1)([CH3:11])[CH3:10]참가 물질
5
실험 절차
2-[4-(Hydroxymethyl)phenyl]propan-2-ol (1.0 g, 6 mmol) was dissolved in the mixture of ethyl acetate (10 mL) and dichloromethane (5 mL). To the solution, MnO2 (2.6 g, 30 mmol) was added, and the mixture was stirred overnight at room temperature. The solid was filtered off and washed with ethyl acetate. The combined organic phases were concentrated to afford the title compound. 1H NMR (400 MHz CDCl3): δ 10.00 (s, 1H), 7.80 (d, 2H), 7.60 (d, 2H), 1.60 (s, 6H).
후처리
- filtrationThe solid was filtered off
- washwashed with ethyl acetate
- concentrationThe combined organic phases were concentrated
출처 및 근거
- ORD 기록
- ord-656c0edb794d41698126c70cd4528d6a
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08278335B2
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