m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 2060609

반응식

HRID 2060609 반응식
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[N+:3]([O-:20])=[CH:4][CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

생성물 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl 2-methylpyridine-3-carboxylate (30 g, 198 mmol) was taken up in DCM (420 mL) and mCPBA (48.9 g, 218 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was purified directly by flash chromatography (silica, 0-20% MeOH/EtOAc) to afford the title compound as a beige solid. 1H NMR (500 MHz, d6-DMSO) δ 8.45 (d, 1H), 7.64 (d, 1H), 7.38 (t, 1H), 3.86 (s, 3H), 2.54 (s, 3H).

후처리

  1. customThe reaction mixture was purified directly by flash chromatography (silica, 0-20% MeOH/EtOAc)

출처 및 근거

ORD 기록
ord-436bf10d20a14af4a037b2488e8b9794
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278335B2

연결된 노트

불러오는 중…