Water → 2-(trifluoromethyl)-1H-indole-5-carbonitrile
반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([F:15])([F:14])[F:13])=[C:6]2C(O)=O)#[N:2].O>CN1C(=O)CCC1>[F:15][C:12]([F:13])([F:14])[C:7]1[NH:8][C:9]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=2참가 물질
4
반응 조건
- 온도
- 135 °C
실험 절차
5-cyano-2-(trifluoromethyl)-1H-indole-3-carboxylic acid (Intermediate 13, 2.09 g) was dissolved in NMP (10 mL) and H2O (1 mL) was then added. The mixture was heated to 130-140° C. overnight under nitrogen. The solution was cooled to room temperature and H2O (30 mL) was added and the solution stirred for 40 min. and then filtered. The cake was washed with H2O. The product is then dried under vacuum at 40° C. to give the title compound (1.42 g);
후처리
- temperatureThe solution was cooled to room temperature
- filtrationfiltered
- washThe cake was washed with H2O
- customThe product is then dried under vacuum at 40° C.
출처 및 근거
- ORD 기록
- ord-a5d6f8507c3b4b8d9e6d0f644a062501
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08283365B2
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