Aluminium lithium hydride → C-[1-(toluene-4-sulfonyl)-cyclopentyl]-methylamine
반응식
[C:1]1([CH3:17])[CH:6]=[CH:5][C:4]([S:7]([C:10]2([C:15]#[N:16])[CH2:14][CH2:13][CH2:12][CH2:11]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[H-].[Li+].[Al+3].[H-].[H-].[H-]>>[C:1]1([CH3:17])[CH:2]=[CH:3][C:4]([S:7]([C:10]2([CH2:15][NH2:16])[CH2:14][CH2:13][CH2:12][CH2:11]2)(=[O:9])=[O:8])=[CH:5][CH:6]=1참가 물질
3
실험 절차
Similarly to Example 1(b), by reaction of 1.1 g (4.4 mmol) of 1-(toluene-4-sulfonyl)-cyclopentanecarbonitrile with 200 mg of aluminum lithium hydride. 400 mg of C-[1-(toluene-4-sulfonyl)-cyclopentyl]-methylamine is obtained in the form of an orange solid. (Yield=36%).
출처 및 근거
- ORD 기록
- ord-e6bcfbf5fa1344ada7054e31bd44f289
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08283378B2
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