Ethanolamine → HCID 59415982, 화합물

HRID 2061824노트

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HRID 2061824 반응식
[CH3:1][N:2]([CH3:43])[CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]3[CH:16]=[N:17][C:18]([NH:30][C:31]([NH:33][CH2:34][CH2:35][CH3:36])=[O:32])=[CH:19][C:20]=3[C:21]3[S:22][CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[N:25]=3)=[CH:12][CH:13]=2)[C:8](=[O:37])[C:7]([C:38](OCC)=[O:39])=[CH:6]1.[CH2:44]([CH2:46][NH2:47])[OH:45]>>[CH3:1][N:2]([CH3:43])[CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]3[CH:16]=[N:17][C:18]([NH:30][C:31]([NH:33][CH2:34][CH2:35][CH3:36])=[O:32])=[CH:19][C:20]=3[C:21]3[S:22][CH:23]=[C:24]([C:26]([F:28])([F:27])[F:29])[N:25]=3)=[CH:12][CH:13]=2)[C:8](=[O:37])[C:7]([C:38]([NH:47][CH2:46][CH2:44][OH:45])=[O:39])=[CH:6]1

참가 물질

3

반응물 2

HCID 700EthanolamineHCID 44540348HCID 44540348, 화합물

생성물 1

HCID 59415982HCID 59415982, 화합물

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온도
87.5 °C

실험 절차

A suspension of ethyl 1-(2-(dimethylamino)ethyl)-4-oxo-6-(6-(3-propylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate (Example 174, 50 mg, 0.09 mmol) in ethanolamine (0.5 mL) was heated to 85-90° C. for 3 h. The reaction mixture was cooled to room temperature and the precipitate that formed was isolated by filtration and washed with acetonitrile and water then dried overnight under high vacuum.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customthe precipitate that formed
  3. customwas isolated by filtration
  4. washwashed with acetonitrile and water
  5. customthen dried overnight under high vacuum

출처 및 근거

ORD 기록
ord-19d9f4ea2c8248ee9975e41e9d046221
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283361B2

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