Potassium Carbonate → Ethyl 6-iodo-1-(1-methoxy-3-methylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

온도

60 °C

To a solution of ethyl 3-(dimethylamino)-2-(2-fluoro-5-iodobenzoyl)acrylate (Intermediate 24, 1 g, 2.56 mmol) dissolved in THF (10 mL) was added 1-methoxy-3-methylbutan-2-amine hydrochloride (366 mg, 2.38 mmol) followed by potassium carbonate. The reaction mixture was stirred at 60° C. for 2 d. The reaction mixture was concentrated under reduced pressure and the residue was resuspended in DMF (10 mL). Potassium carbonate was added (978 mg, 7.08 mmol), and the reaction mixture was stirred at 70° C. for 2 h. The reaction mixture was cooled down to room temperature and quenched with 1 N HCl. The reaction mixture was partitioned between water (20 mL) and ethyl acetate (20 mL). The aqueous layer was extracted with ethyl acetate, and the organics were dried and concentrated to provide ethyl 6-iodo-1-(1-methoxy-3-methylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (623 mg, 60%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionPotassium carbonate was added (978 mg, 7.08 mmol)
3. stirringthe reaction mixture was stirred at 70° C. for 2 h
4. temperatureThe reaction mixture was cooled down to room temperature
5. customquenched with 1 N HCl
6. customThe reaction mixture was partitioned between water (20 mL) and ethyl acetate (20 mL)
7. extractionThe aqueous layer was extracted with ethyl acetate
8. customthe organics were dried
9. concentrationconcentrated

ORD 기록

ord-2fa1c5dc513a41159369f90119a746f4

출처 데이터셋

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08283361B2