Ammonia → HCID 67029027, 화합물

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[C:1]([O:5][C:6]([N:8](C(OC(C)(C)C)=O)[C:9]1[CH:10]=[C:11]([C:16]([Br:19])=[CH:17][N:18]=1)[C:12](OC)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:27]>CO>[Br:19][C:16]1[C:11]([C:12](=[O:13])[NH2:27])=[CH:10][C:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[N:18][CH:17]=1

참가 물질

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온도: 50 °C

실험 절차

A solution of methyl 2-(bis(tert-butoxycarbonyl)amino)-5-bromoisonicotinate (Intermediate 83, 100 g, 232 mmol) in 7 N ammonia in methanol (600 mL) was allowed to stir at 50° C. in a 1 L sealed tube overnight. The resulting mixture was evaporated to dryness and the crude product was directly used for the next step without further purification.

후처리

customsealed tube overnight
customThe resulting mixture was evaporated to dryness
customthe crude product was directly used for the next step without further purification

출처 및 근거

ORD 기록: ord-85c01f4f694b483b817b39e11631e9df
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08283361B2

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참가 물질

반응물 2

HCID 222Ammonia

HCID 67028723HCID 67028723, 화합물2회

생성물 1

HCID 67029027HCID 67029027, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도: 50 °C

실험 절차

후처리

customsealed tube overnight
customThe resulting mixture was evaporated to dryness
customthe crude product was directly used for the next step without further purification

출처 및 근거

ORD 기록: ord-85c01f4f694b483b817b39e11631e9df
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08283361B2

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불러오는 중…