4-Phenylpiperidine → 1-Piperidinesulfonamide, 4-phenyl-

HRID 2061915노트

반응식

HRID 2061915 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:13](N)([NH2:16])(=[O:15])=[O:14]>O1CCOCC1>[NH2:16][S:13]([N:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)(=[O:15])=[O:14]

참가 물질

4

반응물 2

HCID 698734-PhenylpiperidineHCID 82267Sulfamide

생성물 1

HCID 119990221-Piperidinesulfonamide, 4-phenyl-

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
100 °C

실험 절차

4-Phenyl-piperidine (10 g, 62 mmol) was dissolved in dioxane (100 mL). Sulfamide (23.8 g, 248 mmol) was then added and the reaction mixture heated to 100° C. for 14 h. The reaction mixture was then cooled to room temperature, quenched by addition of 1N HCl and then concentrated to remove dioxane. The product was extracted with ethyl acetate (100 mL), dried (Na2SO4), filtered and concentrated to yield the title compound as a light brown solid.

후처리

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. customquenched by addition of 1N HCl
  3. concentrationconcentrated
  4. customto remove dioxane
  5. extractionThe product was extracted with ethyl acetate (100 mL)
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d0a30a179f2d44099ca63f03c1ba702d
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283478B2

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