Anthranilamide → N-(2-carbamoylphenyl)-2-chloro-6-methoxybenzamide

HRID 2062220

반응식

HRID 2062220 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[C:13]=1[C:14](Cl)=[O:15]>N1C=CC=CC=1>[C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[NH:1][C:14](=[O:15])[C:13]1[C:17]([O:21][CH3:22])=[CH:18][CH:19]=[CH:20][C:12]=1[Cl:11])(=[O:5])[NH2:6]

참가 물질

4

반응물 2

HCID 6942AnthranilamideHCID 12892677HCID 12892677, 화합물

생성물 1

HCID 58010809N-(2-carbamoylphenyl)-2-chloro-6-methoxybenzamide수율 86%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
0 °C

실험 절차

2-Amino-benzamide (6.9 g, 50.8 mmol) was dissolved in 50 mL of pyridine and cooled to 0° C. 2-Chloro-6-methoxy-benzoyl chloride was added dropwise to the solution. After complete addition, the reaction was left to stir at room temperature for three days, which resulted in formation of a brown, cloudy solution. The reaction mixture was then poured into 150 mL of ice water. The precipitate was filtered and washed twice with water, twice with THF and finally twice with CH2Cl2 to obtain N-(2-carbamoylphenyl)-2-chloro-6-methoxybenzamide (13.3 g, 43.7 mmol, 86%).

후처리

  1. additionAfter complete addition
  2. waitthe reaction was left
  3. customwhich resulted in formation of a brown, cloudy solution
  4. filtrationThe precipitate was filtered
  5. washwashed twice with water, twice with THF and finally twice with CH2Cl2

출처 및 근거

ORD 기록
ord-ed138ef0553e4cf8ae1643b406823634
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283354B2

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