Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 8-(cyclopentyloxy)-7-methoxy-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one | HCID 77174792 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 8-(cyclopentyloxy)-7-methoxy-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate | HCID 86618132 | — |
반응 단계
4-Methylbenzene-1-sulfonyl chloride (135 mg, 0.71 mmol) was added to a solution of 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one (175 mg, 0.63 mmol), pyridine (0.15 mL, 1.85 mmol), and anhydrous dichloromethane (4 mL) at rt under N2. After 20 h, the reaction was concentrated and purified by silica gel chromatography (1:0→7:3; hexanes:ethyl acetate) to give 8-(cyclopentyloxy)-7-methoxy-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate: MS (ESI): 431.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745646B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-5723064d63964d548591af3a350eda5e |
| 출처 메모 | uspto-grants-2010_06 |