1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester

HRID 2063270노트

반응식

HRID 2063270 반응식
[C:1]([O:5][C:6]([N:8]([CH3:18])[C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CN.C(N)C.[Cl:24]CCCl>>[C:1]([O:5][C:6](=[O:7])[N:8]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:24])=[O:14])=[CH:11][N:10]=1)[CH3:18])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 4

HCID 111,2-DichloroethaneHCID 6329MethylamineHCID 6341EthylamineHCID 667695966-((tert-Butoxycarbonyl)(methyl)amino)nicotinic acid

생성물 1

HCID 86664608(5-Chlorocarbonyl-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester

실험 절차

6-(tert-Butoxycarbonyl-methyl-amino)-nicotinic acid (12.5 g, 47.0 mmol) [prepared analogously to A-05 using methylamine in stead of ethylamine] is taken up in 300 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (10.0 mL, 74.8 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe crude product is used in the next step without purification

출처 및 근거

ORD 기록
ord-e8c22a70c07443e499cf9bd59d47ddc2
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288379B2

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