Acetohydrazide → HCID 57650585, 화합물

HRID 2063476노트

반응식

HRID 2063476 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11]([C@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=S)[CH3:9])=[CH:4][CH:3]=1.[C:25]([NH:28][NH2:29])(=O)[CH3:26]>C(#N)C.C([O-])(=O)C.[Hg+2].C([O-])(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[C:25]([CH3:26])=[N:28][N:29]=[C:11]2[C@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH3:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 14039AcetohydrazideHCID 57650584HCID 57650584, 화합물

생성물 1

HCID 57650585HCID 57650585, 화합물

시약·촉매·용매 2

HCID 15337Mercuric acetate촉매HCID 6342Acetonitrile용매

실험 절차

To a mixture of the product of Step B (1.7 g, 4.6 mmol) and acetic hydrazide (0.76 g, 9.2 mmol) in 30 ml acetonitile was added mercury (II) acetate (2.2 g, 6.9 mmol) and the mixture was stirred at room temperature for overnight. The mixture was filtered over a Celite-fritted funnel and washed with more acetonitrile. The filtrate was concentrated in vacuo. Run wash column yield the desired product containing minor impurities (1.3 g, 72%), was used in the next step without further purification.

후처리

  1. filtrationThe mixture was filtered over a Celite-fritted funnel
  2. washwashed with more acetonitrile
  3. concentrationThe filtrate was concentrated in vacuo
  4. washRun wash column

출처 및 근거

ORD 기록
ord-c239f37011df4052a4fc9114b05adc20
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288371B2

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