5-Benzyl-1,2,4-oxadiazol-3-amine → 5-(5-Benzyl-[1,2,4]oxadiazol-3-ylamino)-2-(4-methyl-imidazol-1-yl)-benzonitrile

HRID 2063642노트

반응식

HRID 2063642 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[CH2:16]([C:23]1[O:27][N:26]=[C:25]([NH2:28])[N:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([C:23]1[O:27][N:26]=[C:25]([NH:28][C:2]2[CH:3]=[CH:4][C:5]([N:10]3[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]3)=[C:6]([CH:9]=2)[C:7]#[N:8])[N:24]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 202997255-Benzyl-1,2,4-oxadiazol-3-amineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

생성물 1

HCID 462160915-(5-Benzyl-[1,2,4]oxadiazol-3-ylamino)-2-(4-methyl-imidazol-1-yl)-benzonitrile

실험 절차

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 5-benzyl-[1,2,4]oxadiazol-3-ylamine (Zeitschrift für Chemie 14, 94 (1974)). The title compound was obtained as a light yellow solid (Yield=41%). MS ISP (m/e): 357.1 (100) [(M+H)+].

후처리

  1. customPrepared in analogy to example 1b)

출처 및 근거

ORD 기록
ord-b3a1977ea91d49f6893d74b943e332fe
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288403B2

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