Aniline → 1-phenyl-1H-1,2,4-triazol-3-amine

HRID 2063651노트

반응식

C1([C:7]2O[N:10]=[C:9]([NH2:12])[N:8]=2)C=CC=CC=1.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([N:13]2[CH:7]=[N:8][C:9]([NH2:12])=[N:10]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 6115Aniline

HCID 23054465-Phenyl-1,2,4-oxadiazol-3-amine

생성물 1

HCID 218217441-phenyl-1H-1,2,4-triazol-3-amine수율 87%

실험 절차

This compound was prepared from 5-phenyl-[1,2,4]oxadiazol-3-ylamine (Journal of Organic Chemistry 28, 1812 (1963) and aniline, via the rearrangement described by Ruccia et al., Journal of Heterocyclic Chemistry 8, 137 (1971). The title compound was isolated as a slightly brownish solid in a yield of 87%. MS ISP (m/e): 161.2 (100) [(M+H)+].

출처 및 근거

ORD 기록: ord-b489db41bb9b418ba091df64ab8fc0b1
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08288403B2

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