1-Benzyl-4-nitro-1H-pyrazole → 1-benzyl-1H-pyrazol-4-amine
반응식
[CH2:1]([N:8]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([N:8]1[CH:12]=[C:11]([NH2:13])[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
3
실험 절차
A mixture of 1-benzyl-4-nitro-1H-pyrazole (33 mg, 0.162 mmol) and 10% Pd/C (10 mg) was stirred under an hydrogen atmosphere at rt for 12 h. The catalyst was filtered off, washed with methanol and the solvent was removed under reduced pressure to give the title compound as dark brown oil (27.4 mg, 97%). MS ISP (m/e): 174.2.3 (100) [(M+H)+].
후처리
- filtrationThe catalyst was filtered off
- washwashed with methanol
- customthe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-024c1dacb96f4352a4e4a4e26830e55c
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08288403B2
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