Ammonia → 3-Benzyl-1,2,4-thiadiazol-5-amine

HRID 2063669

반응식

HRID 2063669 반응식
[CH2:1]([C:8]1[N:12]=[C:11](Cl)[S:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:14]>>[CH2:1]([C:8]1[N:12]=[C:11]([NH2:14])[S:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 147635213-Benzyl-5-chloro-1,2,4-thiadiazole

생성물 1

HCID 6055933-Benzyl-1,2,4-thiadiazol-5-amine

반응 조건

온도
50 °C

실험 절차

A mixture of 3-benzyl-5-chloro-[1,2,4]thiadiazole (105 mg, 0.5 mmol) in ammonia (2 N in MeOH, 2 ml) was heated in a pressure tube at 50° C. for 5 h. The solvents were evaporated, the residue diluted with dichloromethane, the white solid (ammonium chloride) was filtered off, the filtrate was concentrated and then purified by silica gel chromatography using dichloromethane/methanol as eluent. The title compound was obtained as a light yellow liquid (40 mg, 41%). MS ISP (m/e): 192.1 (100) [(M+H)+].

후처리

  1. customThe solvents were evaporated
  2. additionthe residue diluted with dichloromethane
  3. filtrationthe white solid (ammonium chloride) was filtered off
  4. concentrationthe filtrate was concentrated
  5. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-627c223dfef649a5a6faf340263f78f3
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288403B2

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